Polynucleotide Treatments

At RiKo Aesthetics, we offer doctor-led polynucleotide treatments designed to improve skin quality, stimulate tissue repair and support long-term skin rejuvenation.

Unlike traditional dermal fillers, polynucleotides do not add volume or change facial contours. Instead, they work by encouraging the skin to repair itself from within, improving hydration, elasticity, texture and overall skin health.

Polynucleotide treatments are particularly effective for delicate areas such as the under-eyes, but can also be used to rejuvenate the face, neck and hands.

What are polynucleotides?

Polynucleotides are highly purified DNA fragments derived from natural sources that have been developed for use in regenerative medicine and aesthetic treatments.

They act as biostimulators, helping to create an environment that supports cellular repair, tissue regeneration and collagen production.

As we age, the skin’s ability to repair itself gradually declines. This contributes to thinning skin, loss of elasticity, fine lines and a dull or tired appearance. Polynucleotides help counteract these changes by supporting the skin’s natural regenerative processes.

Rather than masking signs of ageing, polynucleotides focus on improving the quality and function of the skin itself.

How do polynucleotides work?

Polynucleotides work by stimulating fibroblast activity and supporting the skin’s natural repair mechanisms.

Following treatment, they help to:

  • Stimulate collagen production
  • Improve skin elasticity
  • Enhance hydration
  • Support tissue repair
  • Reduce inflammation
  • Improve skin texture
  • Strengthen fragile skin
  • Promote healthier cellular function

Over time, these effects lead to stronger, healthier and more resilient skin.

Because polynucleotides work through regeneration rather than volume replacement, results develop gradually over several weeks following treatment.

What areas can be treated?

Under-Eyes

One of the most popular applications of polynucleotide treatment. The delicate skin around the eyes is often one of the first areas to show signs of ageing.

Polynucleotides may help improve:

  • Crepey skin
  • Fine lines
  • Skin quality
  • Mild dark circles associated with thin skin
  • Skin laxity beneath the eyes

Treatment is particularly suitable for patients who want rejuvenation without adding volume to the tear trough area.

Full Face

Polynucleotides can improve overall skin quality across the face by:

  • Enhancing hydration
  • Improving elasticity
  • Softening fine lines
  • Improving texture
  • Supporting collagen production

Neck

The neck is often overlooked despite showing visible signs of ageing.

Treatment can help improve:

  • Fine lines
  • Skin crepiness
  • Texture
  • Skin firmness

Hands

The hands are frequently exposed to environmental damage and can show signs of ageing through thinning skin and reduced elasticity.

Polynucleotides can help improve:

  • Skin quality
  • Hydration
  • Texture
  • Overall appearance of ageing hands

Who is suitable for dermal fillers?

Polynucleotides may be suitable if you:

  • Have thin or fragile skin
  • Are concerned about under-eye ageing
  • Want to improve skin quality naturally
  • Have fine lines and crepey skin
  • Want a regenerative approach to facial rejuvenation
  • Are seeking prevention as well as correction of age-related skin changes
  • Prefer subtle improvements rather than volume enhancement

Polynucleotide treatments may not be suitable for patients who:

  • Are pregnant or breastfeeding
  • Have active infections in the treatment area
  • Have certain autoimmune or inflammatory conditions
  • Are experiencing acute illness
  • Have uncontrolled medical conditions
  • Have known allergies to treatment components

Suitability is assessed during consultation and medical screening.

What to expect at your appointment

Your journey begins with a detailed consultation led by an experienced doctor.

Step 1: Consultation

  • Medical history review
  • Skin assessment
  • Discussion of concerns and goals
  • Evaluation of skin quality
  • Development of a personalised treatment plan

Step 2: Treatment

  • Following cleansing of the skin, small amounts of polynucleotide product are placed into the treatment area using a series of carefully positioned injections.
  • Most treatments take approximately 30–45 minutes.
  • A topical anaesthetic may be used to improve comfort where appropriate.
  • Immediately Afterwards you may notice:
    • Small injection marks
    • Mild swelling
    • Mild redness
    • Temporary tenderness
  • These effects typically settle within a few days.

Step 3: Aftercare guidance

  • Clear instructions to optimise results and reduce risk
  • Most patients return to normal activities immediately following treatment.

What results can you expect?

Polynucleotides work gradually by stimulating tissue repair and regeneration.

Patients commonly notice:

  • Improved skin hydration
  • Increased skin elasticity
  • Smoother texture
  • Reduction in crepey skin
  • Healthier skin appearance
  • Improved skin firmness
  • Brighter and fresher-looking skin

Results develop progressively over several weeks as collagen production and tissue repair occur.

For optimal results, a course of treatment is usually recommended.

Most patients undergo an initial course of 2–4 treatments spaced several weeks apart, followed by maintenance treatments as required.

Safety and clinical standards

At RiKo Aesthetics, safety is prioritised through:

  • Doctor-led care with over 8 years of clinical experience
  • Advanced knowledge of facial anatomy and vascular structures
  • Comprehensive medical screening before treatment
  • Use of regulated, evidence-based products
  • Strict hygiene and infection control protocols
  • Full emergency preparedness and complication management training

You will be fully informed of all risks during your consultation.

Aftercare advice

For the first 24 hours:

  • Avoid touching the treated area unnecessarily
  • Avoid strenuous exercise
  • Avoid alcohol where possible
  • Avoid excessive heat exposure
  • Avoid makeup for several hours if advised

For the following week:

  • Use daily SPF protection
  • Maintain good hydration
  • Follow your recommended skincare routine
  • Avoid aggressive exfoliation or active skincare products if advised

If you experience increasing pain, significant swelling, blanching of the skin or any visual disturbance, contact the clinic immediately.

Frequently Asked Questions

  • Are polynucleotides the same as dermal fillers?
    No. Dermal fillers restore volume and shape, whilst polynucleotides focus on tissue repair, regeneration and skin quality improvement.
  • How many treatments will I need?
    Most patients benefit from an initial course of 2–4 treatments followed by maintenance sessions.
  • When will I see results?
    Some improvements in hydration may be noticed within a few weeks, with continued improvements developing over several months as collagen production increases.
  • Can polynucleotides be used under the eyes?
    Yes. Under-eye rejuvenation is one of the most common and effective uses of polynucleotide treatment.
  • Can I combine polynucleotides with other treatments?
    Yes. Polynucleotides are frequently combined with anti-wrinkle treatments, skin enhancing treatments, microneedling and medical-grade skincare as part of a comprehensive rejuvenation plan.
  • Will I look different?
    Polynucleotides do not alter facial shape or volume. The goal is healthier, stronger and more youthful-looking skin rather than an altered appearance.

Why choose RiKo Aesthetics?

Choosing the right clinic is one of the most important decisions you can make.

At RiKo Aesthetics, we offer:

Doctor-led expertise
Your treatment is performed by a medically trained professional with a deep understanding of facial anatomy, complications, and patient safety.

Natural, tailored results
No “one-size-fits-all” approach – every plan is personalised to your features and goals.

Ethical practice
We prioritise what is medically and aesthetically appropriate. If a treatment isn’t right for you, we will always say so.

Ongoing support
From consultation through to aftercare and review, your journey is fully supported.

Book your consultation

If you are considering polynucleotides, the first step is a personalised consultation.

This ensures:

  • Treatment is safe and appropriate
  • Your goals are fully understood
  • You receive honest, expert guidance

At RiKo Aesthetics, we believe informed patients achieve the best outcomes — and your safety will always come first.

Book Now